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Taking pregabalin Lyrica during pregnancy may be associated with a higher risk of major birth defects, researchers.

In a prospective, nonrandomized study, women who took pregabalin while pregnant were more likely to have babies with major birth defects 6. Women who'd taken the drug also had a lower live birth rate compared wihle the can u take lyrica while pregnant group The study authors concluded that women taking pregabalin during pregnancy perhaps may need more advanced fetal monitoring.

Can u take lyrica while pregnant

The FDA currently classifies the drug as pregnancy category C, indicating that teratogenic effects have been seen in animal studies but there are "no adequate and well controlled studies in pregnant women. Max Wiznitzer, MDof UH Rainbow Babies and Children's Hospital in Cleveland, who was not involved in the study, said kl massage center raises important questions, but is "not definitive proof" that pregabalin causes these birth defects lytica the study was small, doesn't hone in on can u take lyrica while pregnant single defect or syndrome and included many mothers-to-be who were also taking other medications.

He said it warranted further research. It's a good study, but it has its limitations," Wiznitzer told MedPage Today.

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Winterfeld and her team worked with eight different teratology information services offices to collect patient data prospectively from to in six European countries. They compared pregabalin-exposed pregnancies with controls matched on teratology information center, age, year, and pregnancy stage. The median daily dose was mg.

The low-median exposure duration was 6 weeks. Pregabalin is approved for treating partial onset seizures, neuropathic pain, and fibromyalgia.

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Pregabalin was prescribed mainly for pain and psychiatric disorders including depression, anxiety, bipolar disorder, and psychosis. Major birth defects seen in the study included whiel chromosomal problems and eight structural problems.

Structures affected included the central nervous system, the skeletal system, the cardiac system and the skin or vascular. Pregabalin usage was also associated with a significantly higher risk for elective or medically necessary pregnancy termination hazard ratio 2. Spontaneous abortions were not significantly more tke with pregabalin.

Can u take lyrica while pregnant

In husbands love 13 newborns who were exposed to pregabalin until delivery, five neonatal complications were reported. Four babies were born with isolated respiratory lygica, withdrawal syndrome, or clavicle fracture. The fifth, whose mother took aspirin until 36 weeks followed by enoxaparin until 38 weeks, developed can u take lyrica while pregnant distress, hypotonia, shock with metabolic acidosis, hepatic cytolysis, and renal insufficiency.

It died at 6 weeks old. The study's main limitation was its lack of a disease-matched control group.

talk to your doctor. researchers do not know if lyrica is safe to take during pregnancy, or if it passes into breast milk. While it is not used as frequently as other anti-epileptic drugs, we do occasionally see women taking pregabalin who are pregnant or planning. WebMD provides important information about Lyrica Oral such as if you can you take Lyrica Oral when you are pregnant or nursing or If Lyrica Oral dangerous.

But other limitations included the different sources for outcome data, lack of family histories, varying follow-up times, and small sample size for monotherapy. Many of the women in the pregabalin group whose children were born with birth defects were taking multiple prescription drugs during pregnancy.

Source Reference: Winterfeld U, et al "Pregnancy outcome following maternal exposure to pregabalin may call for concern" Neurology ; DOI: Action Points Note that this observational study documented an association between pregabalin use during pregnancy and major birth defects. Be aware lydica study could not adjust for several important confounders, and thus should be interpreted with caution.

Primary Source Neurology Source Reference: